Building `validated' mouse models of human cancer

As a model system for the understanding of human cancer, the mouse has proved immensely valuable. Indeed, studies of mouse
models have helped to define the nature of cancer as a genetic disease and demonstrated the causal role of genetic events found in
tumors. As the scientific and medical community's understanding of human cancer becomes more sophisticated, however, limitations
and potential weaknesses of existing models are revealed. How valid are these murine models for the understanding and treatment of
human cancer? The answer, it appears, depends on the nature of the research requirement. Certain models are better suited for
particular applications. Using novel molecular tools and genetic strategies, improved models have recently been described that
accurately mimic many aspects of human cancer.

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