pythoness - 1375, "woman with the power of soothsaying," from O.Fr. phitonise (13c.), from L.L. pythonissa, used in Vulgate of the Witch of Endor (I Sam. xxviii. 7), and often treated as her proper name, lit. fem. of pytho "familiar spirit;" which ultimately is connected with the title of the prophetess of the Delphic Oracle, Gk. pythia hiereia, from Pythios, an epithet of Apollo, from Pytho, older name of the region of Delphi (see python).